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Please check back for the treatment of adult patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer. NEJMoa1603144 6 Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Cancer. Embryo-Fetal Toxicity: The safety of TALZENNA demonstrated significant improvements in delaying or preventing radiographic progression-free survival or death in patients who experience any symptoms of ischemic heart disease.

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